Post on 10-Jul-2020
EXPOSING HARMFUL INGREDIENTS INDIETARY SUPPLEMENTS
EXPOSING HARMFUL INGREDIENTS INDIETARY SUPPLEMENTS
NOT THE FIRST TIME: NSF researchers havefound potentially harmful compounds in supplements on four occasions.
2016 2014
2013 2013
OxilofrineDMBA
DMAA DEPEA
PHARMACOLOGIC EFFECTSSIMILAR TO DMAA AND EPHEDRINE
Researchers at NSF International recently identi�ed unlabeledDMAA-like stimulants in over-the-counter weight-loss andpre-workout products currently available worldwide.1
Game Day
Infrared
2-aminoisoheptane
Simply Skinny Pollen
Cannibal Ferox AMPED
Triple X Gold Star
Chaos and Pain
Bee Fit with Trish
Chaos and Pain
Gold Star
MAN Sports Octodrine
1,3-DMAA*
1,4-DMAA
1,3-DMAA*1,4-DMAA
1,3-DMBA*
1,4-DMAA
Product Manufacturer Unapproved Compounds
*Previously found to be unlawful dietary ingredient by the U.S. FDA
Products Tested
2-AMINOISOHEPTANE A. KUSNEZOFFII
© 2017 NSF International. All rights reserved.
1 Four experimental stimulants found in sports and weight-loss supplements: 2-amino-6-methylheptane (octodrine), 1,4-dimethylamylamine (1,4-DMAA), 1,3-dimethylamylamine (1,3-DMAA) and 1,3-dimethylbutylamine (1,3-DMBA). Clinical Toxicology.www.tandfonline.com/doi/full/10.1080/15563650.2017.1398328.
2 Potentially Harmful Adulterant Called N,alpha-diethylphenylethylamine (N,a-DEPEA) Found in a Dietary Supplement. NSF International website.www.nsf.org/newsroom/emerging-and-potentially-harmful-adulterant-depea-found-in-supplements. Accessed June 5, 2017.
3 DMAA in Dietary Supplements. U.S. Food and Drug Administration website. www.fda.gov/food/dietarysupplements/productsingredients/ucm346576.htm. Accessed June 5, 2017.
4 DMBA in Dietary Supplements. U.S. Food and Drug Administration website. www.fda.gov/food/dietarysupplements/productsingredients/ucm444719.htm. Accessed June 5, 2017.
5 Scientists at NSF International say oxilofrine could be disguised or unlisted on the label and pose serious health risks to consumers.NSF International website. www.nsf.org/newsroom/unapproved-ephedrine-like-stimulant-oxilofrine-found-in-14-dietary-suppleme.Accessed June 5, 2017.
6 Supplements and Health: Sorting the Facts. Harvard T.H. Chan School of Public Health website.https://theforum.sph.harvard.edu/events/supplements-and-health. Accessed June 5, 2017.
DMAA DMBA
ILLEGAL INGREDIENTS
1,4-DMAA Octodrine
UNAPPROVED INGREDIENTS
HIDDEN STIMULANTS: WHAT ARE THE RISKS?
DEPEA – Risk of heart attack.2
DMAA – Elevated blood pressure andcardiovascular problems.3
DMBA – Risk of heart attacks, seizuresand neurological conditions.4
Oxilofrine – Nausea and vomiting, tachycardia, chest pain and cardiac arrest.5
CARDIOVASCULAR RISKS INCREASE WHENPRODUCTS COMBINED WITH CAFFEINE OR EXERCISE.
High-Risk Categories of Supplements6
Weight loss Pre-workoutMusclebuilding
Sexualperformance
HOW TO CHOOSESAFER DIETARY SUPPLEMENTS
Avoid productscontaining
“2-aminoisoheptane”or “Aconitumkusnezof�i”
Look for theNSF mark
on certi�eddietary
supplements
“2-aminoisoheptane” and “Aconitum kusnezoffii” appear to be
new disguises for illegal and unapproved synthetic stimulants.1
DISGUISING HARMFUL INGREDIENTS
DMAA Octodrine
DMBA1,4-DMAA
2-aminoisoheptane2-aminoisoheptane
NSF-CERTIFIED PRODUCTS ARE:
Tested to verify product formulation and label claims.
Tested for harmful levels of specific contaminants and fraudulent ingredients.
Produced in manufacturing facilities that are inspected twice a year to complywith U.S. FDA Good Manufacturing Practices (GMPs).
Unapproved stimulants found in productscontaining “2-aminoisoheptane” and “Aconitum kusnezof�i.”
A New DMAA Analog1,4-DMAA appears to be a novel compound
never tested on humans. This newly identified
compound is similar to the stimulant DMAA.
NSF’s research team sees no evidencethat 2-aminoisoheptane is a legitimatedietary ingredient derived from plants.1
Aconitumkusnezoffii