Program

Falk Symposium 182

Carcinogenesis, Prevention and Treatment of Colorectal Cancer – State-of-the-Art 2012

February 10 – 11, 2012The Westin Grand Hotel Munich, Germany

Jointly co-organizedwith the ICRCC

CME credits 12

Awarded with

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Preface . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4

Scientific Program . . . . . . . . . . . . . . . . . . . . . . . . . 6

Posters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11

List of Speakers . . . . . . . . . . . . . . . . . . . . . . . . . . . 19

Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25

12 credit hours (CME) have been awarded for the Falk Symposium 182 by the European Union of Medical Specialists (UEMS) - European Board of Gastroenterology (EBG).

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Preface

The World Health Organization (WHO) reported more than 600,000 deaths due to colorectal cancer in 2008 worldwide. The majority of these cancers could be prevented by the wide use of existing knowledge on cancer prevention, established screening methods and the use of modern treatment modalities. Since most colorectal cancers develop from adenomatous polyps, most cancers could be prevented by screening colonoscopies. The current understanding of carcinogenesis in colorectal cancer has led to improved diagnostic and therapeutic tools, which increase the probability of long-term survival of colorectal cancer. Major improvements have been achieved in endoscopy, surgery, chemo-therapy and radio-oncology over the last years. Therefore, all colorectal cancer patients should be discussed in interdisciplinary tumor boards to determine the best individualized treatment plan, based on current knowledge in each clinical specialty.

The aim of this international symposium „Carcinogenesis, Prevention and Treatment of Colorectal Cancer – State of the Art 2012” is to discuss the up-to-date colorectal cancer knowledge with basic and clinical researchers, general practitioners and colorectal cancer specialists in a wide interdisciplinary setting. We expect the participation of a high number of renowned experts from all over the world to increase our knowledge about colorectal cancer in regard to our all mission to prevent and cure cancer.

We would like to thank the Falk Foundation for the generous support and for the chance to organize such an extraordinary and important meeting in Munich. We are convinced that this International Falk Symposium 2012 will lead to a fruitful discussion about colorectal cancer and we would like to invite you all to participate and to benefit from our meeting in Munich. Welcome to Munich!

Helmut Friess, Munich Michael Fried, ZurichRoland M. Schmid, Munich Cornelis van de Velde, Leiden

Falk Symposium 182

Carcinogenesis, Prevention and Treatment of Colorectal Cancer – State of the Art 2012

The Westin Grand HotelMunich, Germany

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Registration:Thursday, February 9, 20128.00 – 18.10 hat the congress offi ce

Jointly co-organizedwith the ICRCC

Scientifi c Organization:H. Friess, Munich (Germany)R. M. Schmid, Munich (Germany)M. Fried, Zurich (Switzerland)C. J. H. van de Velde, Leiden (The Netherlands)

Congress Secretary:R. Rosenberg, Baden (Switzerland)F. G. Bader, Munich (Germany)S. von Delius, Munich (Germany)

Congress Venue:The Westin Grand HotelArabellastr. 681925 MunichGermany

Information:Prof. Dr. Helmut FriessDepartment of SurgeryKlinikum rechts der IsarTechnische Universität MünchenIsmaninger Str. 2281675 MünchenGermanyTelephone: +49(0)89/4140 21 21Telefax: +49(0)89/4140 48 70E-mail: colon2012@chir.med.tu-muenchen.de

Offi cial Language:English

Posters:For details see page 11

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Friday, February 10, 2012

8.30 Opening remarks H. Friess, R. M. Schmid, Munich

Session I Histopathological work-up, carcinogenesis and tumor dissemination

Chair: H. Höfler, Munich; A. Perren, Berne

8.40 State-of-the-Art Lecture

Histopathological work-up of biopsies, local excisions P. Quirke, and resection specimens in colorectal cancer Leeds

9.05 Molecular pathological pathways in the development T. Kirchner, of colorectal cancer Munich

9.30 Mechanism of dissemination and metastases C. A. Klein, Regensburg

9.55 MicroRNAs and inflammatory cytokines are associated C. C. Harris, with diagnosis, prognosis and therapeutic outcome Bethesda of colon cancer

10.20 Coffee break with poster session

Session II From bench to bed – Molecular markers for clinical use

Chair: F. R. Greten, Munich; K.-P. Janssen, Munich; U. J. Roblick, Lübeck

10.50 Molecular, blood and stool tests: T. F. Imperiale, ready to replace colonoscopy? Indianapolis

11.15 Genetic and epigenetic mutations and targeted S. Tejpar, therapies in colon cancer – Have we made progress? Leuven

11.40 Towards personalization in colon cancer – D. J. Kerr, The impact of gene signatures and MSI status Oxford

12.10 Lunch break with poster session

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Friday, February 10, 2012

Session III Screening- and surveillance programs in low/high risk patients

Chair: M. Fried, Zurich; B. Göke, Munich

13.10 Colorectal cancer screening: Practice guidelines D. A. Lieberman, Portland

13.35 Hereditary colorectal cancer: Identification, surveillance J. Burn, and therapy strategies Newcastle

14.00 Inflammatory bowel disease: Cancer risk, detection G. Rogler, and surveillance Zurich

14.25 Chemoprevention of colorectal cancer with 5-ASA H. Herfarth, Chapel Hill

14.50 Coffee break with poster session

Session IV Screening modalities, endoscopic adenoma detection and therapy

Chair: M. F. Neurath, Erlangen; R. M. Schmid, Munich

15.20 CT and MR colonography – Challenge for endoscopy D. C. Rockey, Dallas

15.45 Endoscopic detection of colorectal adenomas: M. Anders, Standards and sophisticated methods T. Rösch, Hamburg

16.10 Mucosectomy in the colorectum B. Saunders, London

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Friday, February 10, 2012

Session V Video session – State-of-the-Art colorectal and liver procedures

Chair: H. Friess, Munich; M. Ghadimi, Göttingen; E. Tiret, Paris

16.35 Complete mesocolic excision K. Weber, W. Hohenberger, Erlangen

17.00 Laparoscopic surgery for lower rectal cancer E. Rullier, Bordeaux

17.25 The Holm’ abdominoperineal resection G. Jansson-Palmer, T. Holm, Stockholm

17.50 Accelerated staged hepatectomy (ASH) for liver tumors P. A. Clavien, Zurich

18.15 End of afternoon session

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Saturday, February 11, 2012

Session VI Polypectomy and tailored surgery

Chair: M. Classen, Reith; C. A. Maurer, Liestal; H. Neuhaus, Düsseldorf

8.30 The “difficult” polyp – Pitfalls for endoscopic removal M. Jung, Mainz

8.55 Endoscopic therapy options for T1 colon and rectal cancer A. Meining, Munich

9.20 Combined endoscopic-laparoscopic resection D. Hahnloser, Lausanne

9.55 The TEM procedure – Standards and extended indications A. Kartheuser, Brussels

10.20 Coffee break with poster session

Session VII Management of non-metastatic colorectal cancer (stage I-III)

Chair: H. J. Buhr, Berlin; K.-W. Jauch, Munich; K.-H. Link, Wiesbaden

10.50 Colorectal surgery – What is evidence-based and E. Tiret, how should we do it? Paris

11.15 Bowel obstruction in stenotic colorectal cancer – P. B. Paty, Stent, stoma or primary resection New York

11.40 Sphincter-saving surgery and reconstruction techniques – A. D’Hoore, What is reasonable in the context of cure and functional Leuven results?

12.05 Multivisceral resection for T4 or recurrent colorectal P. R. O‘Connell, cancer Dublin

12.30 Adjuvant therapy of colon cancer – Present guidelines W. Schmiegel, and future perspectives Bochum

12.55 Lunch break with poster session

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Saturday, February 11, 2012

Session VIII Multimodal therapy in stage II / III rectal cancer

Chair: M. Molls, Munich; C. J. H. van de Velde, Leiden; S. D. Wexner, Weston

14.00 Neoadjuvant short- or long-term radio-(chemo)therapy: C. Rödel, How and who should be treated? Frankfurt

14.25 Specimen evaluation and histopathologic prognosticators M. Berho, after neoadjuvant therapy in rectal cancer Weston

14.45 Complete response after neoadjuvant therapy in S. D. Wexner, rectal cancer: To operate or not to operate? Weston

15.05 Which patient does not need a preoperative radiation? M. Büchler, Heidelberg

15.30 Qualitiy assurance in rectal cancer treatment C. J. H. van de Velde, Leiden

15.55 Presentation of poster prizes

Chair: B. Bashankaev, Moscow; D. Kandioler, Vienna; A. Nissan, Jerusalem

16.10 Coffee break with poster session

Session IX Management of patients with stage IV colorectal cancer

Chair: C.-T. Germer, Würzburg; A. Tuchmann, Vienna; M. Fried, Zurich

16.40 Synchronous resectable colorectal liver metastases B. Nordlinger, Boulogne

17.05 Oncological management of irresectable liver metastases E. van Cutsem, Leuven

17.30 Surgical results after downstaging of initially marginal J. Belghiti, or non-resectable liver metastases Paris

17.55 Hyperthermic intraperitoneal chemoperfusion HIPEC in R. Salazar, peritoneal carcinomatosis Barcelona

18.20 End of meeting

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Poster SessionPosters will be exhibited on February 10 - 11, 2012, at the Westin Grand Hotel in Munich. The authors will be in attendance during coffee and lunch breaks on both days.

Poster JuryB. Bashankaev, Moscow; A. Bembenek, Hannover; D. Kandioler, Vienna; M. E. Kreis, Munich; A. Nissan, Jerusalem; C. T. Viehl, Basel

1. The sphincter‘s fate in low lying rectum cancer: A decision analysis M. Adamina, S. Wolf, B. Hummel, F. Näf, S. Bischofberger, T. Steffen (St. Gallen, CH)

2. Results of intraoperative pelvic hyperthermic chemotherapy for treatment of locally advanced rectal carcinoma

M. Alekseev, E. Rybakov (Moscow, RU)

3. Extranodal non-Hodgkin‘s lymphomas of gastrointestinal tract D. Badea, M. Badea, A. Genunche-Dumitrescu (Craiova, RO)

4. Incidence and clinical evolution of non-Hodgkin lymphoma (NHL) of the colon M. Badea, D. Badea, A. Genunche-Dumitrescu, L. Stefan, A. Badea, D. Duta

(Craiova, RO)

5. The Ann Arbor Staging system versus modified Blackledge Staging system and Musoff system in the gastrointestinal lymphoma

M. Badea, D. Badea, A. Genunche-Dumitrescu, C. Petrica, D. Iordache, L. Stefan, D. Duta, A. Badea (Craiova, RO)

6. Capnography improves patient safety during propofol sedation for colonoscopy: A randomized, controlled study (ColoCap Study)

A. Beitz, A. Riphaus, A. Meining, T. Kronshage, C. Geist, S. Wagenpfeil, A. Weber, A. Jung, M. Bajbouj, C. Pox, G. Schneider, R.M. Schmid, T. Wehrmann, S. von Delius (Bochum, Munich, Wuppertal, Wiesbaden, DE)

7. Are there other indicators of quality of colonoscopy than adenoma detection rate (ADR)?

M. Benes, P. Drastich, T. Hucl, P. Stirand, P. Wohl, J. Spicak (Prague, CZ)

8. Quality of endoscopic mucosal resection (EMR) at IKEM M. Benes, P. Drastich, P. Stirand, P. Wohl, T. Hucl, J. Spicak (Prague, CZ)

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9. Compartmental differences of circulating tumor cells in colorectal cancer U. Bork, N.N. Rahbari, A. Kircher, E. Seyfarth, T. Niemetz, S. Schölch, C. Kahlert,

M.W. Büchler, M. Koch, J. Weitz (Heidelberg, DE)

10. Non-invasive screening for colorectal cancer and colon adenomas S. Chernyshov, E. Zenkina (Moscow, RU)

11. Is the prevalence of colorectal adenoma higher in patients with gastric neoplasm? C.H. Choi, B.K. Cha, I.D. Song, S.Y. Yang, S.K. Chang (Seoul, KR)

12. Gradual loss of functional gap junction within progression from colorectal adenoma to cancer – A shift from membranous CX32 and CX43 expression to cytoplasmic pattern during colorectal carcinogenesis

R. Dereniewicz-Wincewicz, A. Wincewicz, L. Kanczuga-Koda, M. Koda, S. Sulkowski (Kielce, Bialystok, PL)

13. Tubulo-villous colorectal adenocarcinoma vs. mucin and signet-ring cell carcinoma – Is there a prognostic difference?

M. Doß, U. Nitsche, M. Maak, T. Schuster, R. Langer, H. Friess, R. Rosenberg (Munich, DE; Baden, CH)

14. High myeloperoxidase positive cell density in colorectal cancer is an independent favorable prognostic factor

R. Droeser, C. Hirt, S. Eppenberger-Castori, I. Zlobec, C. T. Viehl, D. Frey, R. Rosso, G. Iezzi, G. Sconocchia, G. Spagnoli, M. Heberer, A. Lugli, L. Terracciano, D. Oertli (Basel, Lugano, Bern, CH; Rome, IT)

15. Postoperative outcome and long-term survival after laparoscopic assisted right hemicolectomy during the learning curve: A case-matched analysis with open approach

T. Dumitrascu, C. Vasilescu, V. Tomulescu, M. Ionescu, I. Popescu (Bucharest, RO)

16. Risk factors for adverse outcome of ermergent colon cancer surgery S. Faes, A. Schnider, M. Weber (Baden, Zurich, CH)

17. Ulcerative colitis as a risk factor for colorectal cancer O.V. Fedorova, E. Fedulova, O. Tutina, O. Shumilova (Nizhny Novgorod, RU)

18. IBD: Cytoprotection for the prevention of colorectal cancer O.V. Fedorova, E. Fedulova, O. Tutina, O. Shumilova (Nizhny Novgorod, RU)

19. HER-2/neu immunoexpression in colorectal and gastric carcinomas O. Fratila, T. Ilias, M. Puscasiu, R.G. Mihaila (Oradea, Sibiu, RO)

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20. Oct4, spliced variant OCT4B1, a novel marker for human colorectal cancer M. Gazouli, G. Theodoropoulos, M. Roubelakis, A. Vaiopoulou, J. Papailiou,

N. Nikiteas, N.P. Anagnou (Athens, GR)

21. Assessment of the local recurrence rates of colorectal cancer after curative resection A. Genunche-Dumitrescu, D. Badea, M. Badea, P. Mitrut, A. Badea (Craiova, RO)

22. The contribution of major etiologic factors to the risk of colorectal cancer A. Genunche-Dumitrescu, D. Badea, M. Badea, P. Mitrut (Craiova, RO)

23. Correlation of prognosis and gene expression signatures in colorectal cancer J. Gröne, L. Lee, J. Lauscher, H. J. Buhr (Berlin, DE)

24. Molecular biomarkers play a major role in the selection of treatment strategies in CRC

J. Gülden, A. Bogner, M. Joka, K.-W. Jauch, B. Mayer (Munich, DE)

25. A genetic mouse model to identify the role of the immune adapter protein MyD88 in colon cancer

A. Holtorf, M. Martini, B. Holzmann, K.-P. Janssen (Munich, DE)

26. Colorectal cancer assessment in a group of patients from the western part of Romania

T. Ilias, O. Fratila, D. Puscasiu (Oradea, RO)

27. Inflammatory response related gene polymorphisms and colorectal cancer G. Karamanolis, G. Theodoropoulos, M. Gazouli (Athens, GR)

28. Laparoscopic surgery for rectal cancer S. Kathy, D. Tóth, Z. Kincses (Debrecen, HU)

29. CXC-chemokines as crucial immune mediators in colorectal carcinogenesis L. Keller, D. Doll, C. Ochs, K.-P. Janssen (Munich, DE)

30. The risk factors of colorectal cancer operations Z. Kincses, T. Csobán, S. Kathy, D. Tóth (Debrecen, HU)

31. Importance of the long-term surveillance of patients with ulcerative colitis considering the occurrence of dysplastic changes and colorectal carcinoma

M. Konecny, V. Prochazka, J. Ehrmann (Olomouc, CZ)

32. Identification of prognostic factors for long-term survival in stage IV colorectal cancer patients

B. Künzli, U. Nitsche, M. Maak, R. Gertler, G. Ceyhan, T. Schuster, C. Meyer-zum-Büschenfelde, H. Friess, R. Rosenberg (Liestal, CH; Munich, DE)

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33. Initial results of a randomized controlled trial comparing clinical and pathological downstaging of rectal cancer after preoperative short-course radiotherapy or conventional chemoradiotherapy with delayed surgery

T. Latkauskas, H. Pauzas, P. Lizdenis, Z. Saladzinskas, A. Tamelis, D. Pavalkis (Kaunas, LT)

34. Radiofrequency-assisted hepatic resections metastases of colorectal cancer A. Lavrinenko, V. Kashnikov, E. Rybakov, Y.A. Shelygin (Moscow, RU)

35. Neural invasion is not a prognostic factor in colon cancer due to missing neuro-cancer cell affinity

F. Liebl, I.E. Demir, R. Rosenberg, T. Kehl, A. Boldis, T. Schuster, M. Maak, K. Becker, R. Langer, M. Laschinger, H. Friess, G. Ceyhan (Munich, DE)

36. Systematic review and meta-analysis on the effect of preoperative radio(chemo)therapy on long-term functional outcome in rectal cancer patients

M. Loos, P. Quentmeier, T. Schuster, U. Nitsche, R. Gertler, A. Keerl, T. Kocher, H. Friess, R. Rosenberg (Munich, DE; Baden, CH)

37. Tumor targeting of gastrointestinal carcinomas with Shiga toxin B M. Maak, U. Nitsche, L. Johannes, R. Rosenberg, H. Friess, K.-P. Janssen

(Munich, DE; Paris, F; Baden, CH)

38. Colonoscopy screening markedly reduces the occurrence of colon carcinomas and carcinoma-related death

C. Manser, L. Bachmann, J. Brunner, F. Hunold, M. Fried, P. Bauerfeind, U.A. Marbet (Zürich, Glarus, Altdorf, CH)

39. Complex pathology analysis of colorectal cancer in children N.S. Marenich, A.S. Tertychnyy, D.M. Konovalov, A.G. Talalaev (Moscow, RU)

40. Microsimulation of colorectal cancer screening B. Misselwitz, C. Manser, L. Biedermann, A. Sonnenberg, P. Bauerfeind (Zürich,

CH; Portland, US)

41. A novel mouse model of orthotopic metastatic colon cancer O. Movadat, A. Wlodarski, N. Wittkopf, M.F. Neurath, C. Becker (Erlangen,

Mainz, DE)

42. Immunohistochemical screening of hMLH1 and hMSH2 gene mutations in patients diagnosed with colorectal cancer and microsatellite instability suspicion

F. Muresan, R. Simescu, I. Domsa, R. Buiga, M. Cazacu (Cluj-Napoca, RO)

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43. Epiregulin promotes growth of colitis-associated tumors C. Neufert, C. Becker, M. Waldner, I. Backert, M.F. Neurath (Erlangen, DE)

44. Prediction of prognosis is not improved by the 7th edition of the TNM classification for colorectal cancer

U. Nitsche, M. Maak, T. Schuster, B. Künzli, R. Langer, J. Slotta-Huspenina, F.G. Bader, K.-P. Janssen, H. Friess, R. Rosenberg (Munich, DE; Liestal, CH)

45. Integrative marker analysis and risk assessment in stage II colon cancer U. Nitsche, A. Balmert, T. Schuster, F.G. Bader, H. Friess, R. Rosenberg, K.-P. Janssen

(Munich, DE)

46. Surgical site infection in diabetic patients after colorectal surgery S. Panidis, D. Paramythiotis, D. Panagiotou, E. Karamanlis, V.N. Papadopoulos,

A. Michalopoulos, G. Basdanis (Thessaloniki, GR)

47. Results of salvage abdominoperineal resection after failed chemoradiation therapy for epidermoid anal canal carcinoma: Retrospective analysis at a single institution

I. Papaconstantinou, A. Yiallourou, T. Theodosopoulos, L. Samanides, V. Smyrniotis, A. Fotopoulos, G. Polymeneas, C. Gennatas, D. Voros (Athens, GR)

48. Gastrointestinal quality of life after laparoscopic-assisted sigmoidectomy for

diverticular disease I. Pasternak, N. Wiedemann, G. Basilicata, G. Melcher (Uster, Liestal, CH)

49. Effect of preoperative radiochemotherapy on lymph node retrieval after resection of rectal cancer

H. Pauzas, T. Latkauskas, P. Lizdenis, Z. Saladzinskas, A. Tamelis, D. Pavalkis (Kaunas, LT)

50. Microvessel density could be strong prognostic marker after radiotherapy in rectal cancer

D. Pavalkis, S. Svagzdys, V. Lesauskaite, Z. Saladzinskas, A. Tamelis (Kaunas, LT)

51. Gasless transanal endosurgery and transanal excision of rectal cancer: Experience from a single center in Moscow

I. Peresada, Y.A. Shelygin, S. Chernyshov (Moscow, RU)

52. Anal sphincter preservation in ultra low rectal cancer surgery – Suffering for the patient or chance to continue customary life?

D. Pikunov, E. Rybakov (Moscow, RU)

53. Adrenal metastases of colorectal carcinomas C. Pitt, K. Peitgen (Bottrop, DE)

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54. Lymph node yield after rectal resection in patients treated with neoadjuvant radiation: A systematic review and meta-analysis

S. Pohle, P. Quentmeier, M. Loos, U. Nitsche, M. Maak, T. Schuster, R. Langer, H. Friess, T. Kocher, R. Rosenberg (Baden, CH; Munich, DE)

55. Preoperative chemoradiotherapy increases sphincter-sparing procedure rate for rectal carcinoma patients

A. Rasulov, Y.A. Shelygin, S. Zhdankina, A. Boiko, I. Droshneva (Moscow, RU)

56. HLA class I expression in colorectal cancer; prognostic and predictive relevance M. Reimers, E. Zeestraten, S. Saadatmand, G. Liefers, C.J.H. van de Velde,

P.J.K. Kuppen (Leiden, NL)

57. Groin metastases of anal carcinoma: Surgery or chemoradiation E. Rybakov, S. Chernyshov (Moscow, RU)

58. Primary mixed goblet cell carcinoid/-adenocarcinoma of the cecum with stenotic metastasis in the sigmoid presents as a rare cause of decompensated colon ileus with sigmoid stenosis

A. Sahin, S. Tschuppert, A. Wodzynski, M. Trippel, S. Saravanja, A. Keerl, R. Rosenberg, T. Kocher (Baden, CH)

59. Quality of life after sphincter-preserving rectal cancer resections J. Scheele, M. Meier, D. Henne-Bruns, M. Kornmann (Ulm, DE)

60. Postoperative complications and risk factors in robotic surgery for rectal cancer O. Sgarbura, M. Eftimie, V. Tomulescu, I. Popescu (Bucharest, RO)

61. Screening of irregular bowel movement frequency as functional risk factor of colorectal cancer

C. Shemerovskii (St. Petersburg, RU)

62. Specific activity of cyclindependent kinase 1 predicts the recurrence of stage II colon cancer

M. Shibayama, E. Zeestraten, M. Maak, T. Schuster, U. Nitsche, T. Matsushima, S. Nakayama, K. Gohda, H. Kurata, H. Friess, C.J.H. van de Velde, H. Ishihara, R. Rosenberg, P.J.K. Kuppen, K.-P. Janssen (Kobe, JP; Leiden, NL; Munich, DE)

63. Colorectal cancer in the region with enormously high occurrence rate: The projection of screening program and clinical practice

J. Spicak, P. Stirand, P. Drastich, T. Hucl, M. Benes, P. Wohl, D. Kamenar, V. Nosek, O. Urban, M. Zavoral (Prague, Jablonec nad Nisou, Ostrava, CZ)

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64. The effect of a nationwide screening program on the diagnosis of colorectal cancer (CRC) in a region with an enormously high occurrence

J. Spicak, M. Benes, T. Hucl, P. Stirand, P. Drastich, O. Urban, V. Nosek (Prague, Ostrava, Jablonec nad Nisou, CZ)

65. Surgical reoperations in cases of postoperative sepsis subsequent to the surgical treatment of colorectal cancer

G. Statescu, A. Statescu, M. Carausu (Iasi, RO)

66. MMP-9 is a strong prognostic survival marker in rectal carcinoma S. Svagzdys, V. Lesauskaite, Z. Saladzinskas, A. Tamelis, D. Pavalkis (Kaunas, LT)

67. N-acetylcysteine has a powerful dual effect of anti-inflammatory and antioxidant activities resulting in complete improvement of acetic acid induced colitis in rats

V. Tahan, S. Uraz, G. Tahan, H. Aytekin (Pittsburgh, US; Istanbul, TR)

68. Prognostic value and prediction of the presence of KRAS mutation on the basis of combined pathology data of colorectal cancer

A.S. Tertychnyy, G. De Hertogh, X. Sagaert, K. Geboes (Moscow, RU; Leuven, BE)

69. Single direct suture of the perineal wound after cylindrical abdominoperineal exstirpation of the rectum (Holm-procedure) – An alternative to a Mesh or flap technique

W. Thasler, M. E. Kreis (Munich, DE)

70. Association of caspase-8 and -9 gene polymorphisms and colorectal cancer susceptibility and prognosis

G. Theodoropoulos, M. Gazouli, A. Vaiopoulou, N. Nikiteas (Athens, GR)

71. Results of extralevator abdomino-perineal resections for rectal cancer (multicenter study)

P.V. Tsarkov, I.A. Nechay, D.A. Hubezov, V.V. Polovinkin, Y.M. Makeev, A.M. Karachun, I. Tulina, M.A. Danilov, I.S. Tsarkov (Moscow, St. Petersburg, Ryazan, Krasnodar, Balashikha, RU)

72. D3 lymph node dissection in right colon cancer: Too much or just enough? P.V. Tsarkov, B. Bashankaev, A. Kravchenko, I. Tulina (Moscow, RU)

73. The effectiveness of the multidisciplinary approach in elective surgery of colorec-tal cancer in elderly patients.

P.V. Tsarkov, V.V. Nikoda, V.I. Stamov, D.R. Markar‘yan, I. Tulina (Moscow, RU)

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74. Pretherapeutic selection of the most promising drugs for the individual CRC patient using the functional Spheroid Microtumor Model

K. Weiler, L. Rava, C. Ludwig, M. Joka, K.-W. Jauch, I. Funke, B. Mayer (Munich, DE)

75. Erythropoietin receptor expression in colorectal cancer – Immunohistochemical and mRNA studies – In perspective of treatment with recombinant EPO in colorectal cancer-associated anemia

A. Wincewicz, C. Miller, C. Blau, U. Sulkowska, S. Sulkowski (Bialystok, PL; Seattle, US)

76. The role of capsule endoscopy in evaluating and managing small bowel disorders E. Yoong, K. Padmakumar (Manchester, Bolton, GB)

77. Stomach and colon cancer diagnosis of vitamin B12 and folic acid levels E. Yorulmaz, V. Cakici, C. Ulasoglu, M. Celik, I. Tuncer, H. Ciftci (Istanbul, TR)

78. Local recurrance rate in rectal cancer W. Zaglmair, H. Wundsam, K. Rohregger, G. Pressl, M. Aufschnaiter, K. Emmanuel

(Linz, AT)

79. Individual CRC-tumour-ID by combining biomarker profiling and functional 3D drug testing

M. Zoller, J. Gülden, M. Joka, I. Funke, K.-W. Jauch, B. Mayer (Munich, DE)

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List of Speakers, Moderators and Scientific Organizers

PD Dr. Mario AndersKlinik und Poliklinik für Interdisziplinäre EndoskopieUniversitätsklinikum EppendorfMartinistr. 5220251 HamburgGermanym.anders@uke.uni-hamburg.de

PD Dr. Franz Georg BaderChirurgische Klinik und Poliklinik Klinikum rechts der Isarder Technischen UniversitätIsmaninger Str. 2281675 MünchenGermany franz.bader@tum.de

Dr. Badma BashankaevNational Research Centerof SurgeryDepartment of Colorectaland Pelvic Floor Surgery2 Abrikosovsky per.119992 MoskauRussiabadma.bashankaev@gmail.com

Prof. Dr. Jacques BelghitiHôpital BeaujonDepartment of Surgery100, Bd. Général Leclerc92118 ClichyFrancejacques.belghiti@bjn.ap-hop-paris.fr

PD Dr. Andreas BembenekKlinik für ViszeralchirurgieKrankenhaus SiloahKlinikum Region HannoverRoesebeckstr. 1530449 HannoverGermanyandreas.bembenek@krh.eu

Mariana Berho, M.D.Professor of MedicineCleveland Clinic FloridaDepartment of Pathology2950 Cleveland Clinic BoulevardWeston FL 33331USAberhom@ccf.org

Prof.Dr.Dr.h.c.mult. Markus BüchlerAbteilung für Allgemeine, Viszerale und TransplantationschirurgieUniversitätsklinikum HeidelbergIm Neuenheimer Feld 11069120 HeidelbergGermanymarkus.buechler@med.uni-heidelberg.de

Prof. Dr. Heinz J. BuhrAllgemein-,Gefäß- und ThoraxchirurgieCharité UniversitätsmedizinCampus Benjamin Franklin (CBF)Hindenburgdamm 3012203 BerlinGermanyheinz.buhr@charite.de

Prof. Sir John BurnInstitute of Genetic MedicineNewcastle UniversityCentral ParkwayNewcastle-upon Tyne NE13BZGreat Britainjohn.burn@ncl.ac.uk

Prof.Dr.Dr.h.c.mult. Meinhard ClassenGolfweg 116370 Reith b. KitzbühelAustriameinhard.classen@lrz.tum.de

Prof. Dr. Pierre-Alain ClavienUniversitätsspital ZürichKlinik für Viszeral- und TransplantationschirurgieRämistrasse 1008091 ZürichSwitzerlandpierre-alain.clavien@usz.ch

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PD Dr. Stefan von DeliusII. Medizinische Klinik und PoliklinikKlinikum rechts der Isarder Technischen UniversitätIsmaninger Str. 2281675 MünchenGermanystefan.von-delius@lrz.tum.de

Prof. Dr. André D‘HooreDepartment of Abdominal Surgery University ClinicsGasthuisbergHerestraat 493000 LeuvenBelgiumandre.dhoore@uz.kuleuven.ac.be

Prof. Dr. Michael FriedUniversitätsspital ZürichKlinik für Gastroenterologie und HepatologieRämistrasse 1008091 ZürichSwitzerlandmichael.fried@usz.ch

Prof. Dr. Helmut FriessChirurgische Klinik und PoliklinikKlinikum rechts der Isarder Technischen UniversitätIsmaninger Str. 2281675 MünchenGermanyhelmut.friess@chir.med.tu-muenchen.de

Prof. Dr. Christoph-Thomas GermerKlinik und Poliklinik für Allgemein- und ViszeralchirurgieKlinikum der Universität WürzburgOberdürrbacher Str. 697080 WürzburgGermanygermer_c@chirurgie.uni-wuerzburg.de

Prof. Dr. Michael GhadimiAbteilung für Allgemein- und ViszeralchirurgieUniversitätskliniken GöttingenRobert-Koch-Str. 4037075 GöttingenGermanymghadim@uni-goettingen.de

Prof. Dr. Burkhard GökeMedizinische Klinik und Poliklinik IIKlinikum der UniversitätMünchen - GroßhadernMarchioninistr. 1581377 MünchenGermanyburkhard.goeke@med.uni-muenchen.de

Prof. Dr. Florian R. GretenII. Medizinische Klinik und PoliklinikKlinikum rechts der Isarder Technischen UniversitätIsmaninger Str. 2281675 MünchenGermanyflorian.greten@lrz.tum.de

Prof. Dr. Dieter HahnloserC.H.U.V.Service de chirurgie viscéraleRue du Bugnon 461011 LausanneSwitzerlanddieter.hahnloser@chuv.ch

Curtis C. Harris, M.D.Professor of MedicineNational Cancer InstituteCenter for Cancer ResearchLaboratory of Human Carcinogenesis31 Center DriveBethesda MD 20892USAcurtis_harris@nih.gov

Hans Herfarth, M.D.Associate Professor of MedicineUniversity of North CarolinaGastroenterology & Hepatology4151 Bioinformatics Bldg.130 Mason Farm RoadChapel Hill NC 27599-7080USAhherf@med.unc.edu

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Prof. Dr. Heinz HöflerInstitut für Allgemeine Pathologie und Pathologische AnatomieKlinikum rechts der Isarder Technischen UniversitätIsmaninger Str. 2281675 MünchenGermanyhoefler@lrz.tu-muenchen.de

Prof. Dr.Dr.h.c. Werner HohenbergerChirurgische Klinik und PoliklinikUniversitätsklinikum ErlangenKrankenhausstr. 1291054 ErlangenGermanywerner.hohenberger@uk-erlangen.de

Prof. Dr. Torbjorn HolmDepartment of Colorectal SurgeryKarolinska UniversityHospital SolnaI171 76 StockholmSwedenholm@karolinska.se

Thomas F. Imperiale, M.D.Professor of MedicineIndiana UniversityDivision of Gastroenterology1050 Wishard Blvd.Indianapolis IN 46202USAtimperia@iupui.edu

PD Dr. Klaus-Peter JanssenChirurgische Klinik und PoliklinikKlinikum rechts der Isarder Technischen UniversitätIsmaninger Str. 2281675 MünchenGermanyklaus-peter.janssen@lrz.tum.de

Dr. Gabriella Jansson-PalmerDepartment of Colorectal Surgery Karolinska UniversityHospital Solma171 76 StockholmSwedengabriella.jansson-palmer@karolinska.se

Prof. Dr. Karl-Walter JauchChirurgische Klinik und PoliklinikKlinikum der UniversitätMünchen - GroßhadernMarchioninistr. 1581377 MünchenGermanykarl-walter.jauch@med.uni-muenchen.de

Prof. Dr. Michael JungKlinik für Innere MedizinKatholisches Klinikum MainzSt. Hildegardis-KrankenhausHildegardstr. 255131 MainzGermanym.jung.hildegardis-mz@t-online.de

Prof. Dr. Daniela KandiolerKlinik für ChirurgieMedizinische Universität WienLeitstelle 21AWähringer Gürtel 18-201090 WienAustriadaniela.kandioler@meduniwien.ac.at

Prof. Dr. Alex KartheuserClinique Universitaire St. LucService de Chirurgiede l‘Appareil DigestifAvenue Hippocrate 101200 BruxellesBelgiumkartheuser@chir.ucl.ac.be

Prof. Dr. David J. KerrUniversity of OxfordDepartment of ClinicalPhramacologyOld Road Campus off Roosevelt DrOxford OX3 7DQGreat Britaindavid.kerr@clinpharm.ox.ac.uk

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Prof. Dr. Thomas KirchnerPathologisches InstitutLMU MünchenThalkirchner Str. 3680337 MünchenGermanythomas.kirchner@med.uni-muenchen.de

Prof. Dr. Christoph A. KleinInstitut für PathologieUniversitätsklinikum Regensburg93042 RegensburgGermanychristoph.klein@klinik.uni-regensburg.de

Prof. Dr. Martin E. KreisChirurgische Klinik und PoliklinikKlinikum der UniversitätMünchen - GroßhadernMarchioninistr. 1581377 MünchenGermanymartin.kreis@med.uni-muenchen.de

David A. Lieberman, M.D.Professor of MedicineOregon Health & Science Univ.Division of GastroenterologyL4613181 SW Sam Jackson Park RoadPortland OR 97239USAlieberma@ohsu.edu

Prof. Dr. Karl-H. LinkChirurgisches ZentrumAsklepios Paulinen KlinikGeisenheimer Str. 1065197 WiesbadenGermanyk-h.link@asklepios.com

Prof. Dr. Christoph A. MaurerKantonsspital Liestal Chirurgische KlinikRheinstr. 264410 LiestalSwitzerlandchristoph.maurer@ksli.ch

Prof. Dr. Alexander MeiningII. Medizinische Klinik und PoliklinikKlinikum rechts der Isarder Technischen UniversitätIsmaninger Str. 2281675 MünchenGermanyalexander.meining@Irz.tum.de

Prof. Dr. Michael MollsKlinik und Poliklinik für StrahlentherapieKlinikum rechts der Isarder Technischen UniversitätIsmaninger Str. 2281675 MünchenGermanymolls@lrz.tum.de

Prof. Dr. Horst NeuhausInnere MedizinEvangelisches KrankenhausKirchfeldstr. 4040217 DüsseldorfGermanyhorst.neuhaus@evk-duesseldorf.de

Prof. Dr. Markus F. NeurathMedizinische Klinik IUniversitätsklinikum ErlangenUlmenweg 1891054 ErlangenGermanymarkus.neurath@uk-erlangen.de

Prof. Dr. Aviram NissanDivision of Surgical OncologyRabin Medical CenterBeilinson CampusDepartment of Surgery BP. O. Box 906449190 Petah TiqvaIsraelanissan@cancer-surgery.co.il

Prof. Dr. Bernard NordlingerHôpital Ambroise ParéDepartment of Digestive Surgery92104 BoulogneFrancebernard.nordlinger@apr.aphp.fr

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Prof. Dr. P. Ronan O‘ConnellSt. Vincent‘s HospitalDepartment of SurgeryElm ParkDublin 4Irelandronan.oconnell@ucd.ie

Philip B. Paty, M.D.Memorial Sloan-KetteringCancer CenterDepartment of SurgeryColorectal Service1275 York AvenueNew York NY 10065USApatyp@mskcc.org

Prof. Dr. Aurel PerrenUniversität BernPathologisches InstitutMurtenstraße 313010 BernSwitzerlandaurel.perren@pathology.unibe.ch

Prof. Dr. Phil QuirkeSt. James‘s University HospitalPathology and Tumour BiologyWellcome Trust Brenner Bldg.Beckett StreetLeeds LS9 7TFGreat Britainp.quirke@leeds.ac.uk

PD Dr.Dr. Uwe Johannes RoblickKlinik f. Allg. ChirurgieUniversitätsklinikum Schleswig-Holstein, Campus LübeckRatzeburger Allee 16023562 LübeckGermanydrdr.ujroblick@me.com

Don C. Rockey, M.D.Professor of MedicineUniversity of TexasSouthwestern Medical CenterDiv. of Digestive & Liver Diseas5959 Harry Hines BoulevardDallas TX 75390USAdon.rockey@utsouthwestern.edu

Prof. Dr. Claus RödelKlinik für Strahlentherapie und OnkologieKlinikum der Johann WolfgangGoethe-Universität FrankfurtTheodor-Stern-Kai 760596 FrankfurtGermanyclaus.roedel@kgu.de

Prof. Dr. Thomas RöschKlinik und Poliklinik für Interdisziplinäre EndoskopieUniversitätsklinikum EppendorfMartinistr. 5220251 HamburgGermanyt.roesch@uke.de

Prof. Dr.Dr. Gerhard RoglerUniversitätsspital ZürichKlinik für Gastroenterologie & HepatologieRämistrasse 1008091 ZürichSwitzerlandgerhard.rogler@usz.ch

Prof. Dr. Robert RosenbergKantonspital BadenKlinik f. Allgmein-, Viszeral- und Gefäßchirurgie5404 BadenSwitzerlandrobert.rosenberg@ksb.ch

Prof. Dr. Eric RullierHôpital Universitaire Saint AndréDepartment of Surgery1 Rue Jeau Burguel33075 Bordeaux CedexFranceeric.rullier@chu-bordeaux.fr

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Prof. Dr. Ramon SalazarInstitut Catalá d‘OncologiaIDIBELLGran Via s/n, Km 2.708907 L‘Hospitalet, BarcelonaSpainramonsalazar@iconcologia.net

Dr. Brian SaundersSt. Mark‘s HospitalWolfson Unit for EndoscopyWatford RoadHarrow HA1 3UJGreat Britainb.saunders@imperial.ac.uk

Prof. Dr. Roland M. SchmidII. Medizinische Klinik und PoliklinikKlinikum rechts der Isarder Technischen UniversitätIsmaninger Str. 2281675 MünchenGermanyroland.schmid@lrz.tum.de

Prof. Dr. Wolff SchmiegelMedizinische UniversitätsklinikRuhr-Universität BochumIn der Schornau 23-2544892 BochumGermanywolff.schmiegel@ruhr-uni-bochum.de

Prof. Dr. Sabine TejparDigestive Oncology UnitUniversity ZiekenhuisGasthuisbergHerestraat 493000 LeuvenBelgiumsabine.tejpar@uz.kuleuven.ac.be

Prof. Dr. Emmanuel TiretHôpital Saint AntoineService de Chirurgie Digestive184, Rue du Faubourg St.-Antoine75571 ParisFranceemmanuel.tiret@sat.aphp.fr

Prof. Dr. Albert TuchmannKrankenhaus FlorisdorfI. Chirurgische AbteilungHinaysgasse 11210 WienAustriaalbert.tuchmann@wienkav.at

Prof. Dr. Eric van CutsemDivision of Digestive Oncology University of LeuvenHerestraat 493000 LeuvenBelgiumeric.vancutsem@med.kuleuven.be

Prof. Dr. Cornelis J.H. van de VeldeAcademisch Ziekenhuis LeidenDep. of SurgeryAlbinusdreef 22333 ZA LeidenThe Netherlandsc.j.h.van_de_velde@lumc.nl

PD Dr. Carsten T. ViehlUniversitätsspital BaselViszeralchirurgieSpitalgasse 214031 BaselSwitzerlandcviehl@uhbs.ch

Dr. Klaus WeberChirurgische Klinik und PoliklinikUniversitätsklinikumErlangen-NürnbergKrankenhausstr. 1291054 ErlangenGermanyklaus.weber@uk-erlangen.de

Steven D. Wexner, M.D.Professor of MedicineCleveland Clinic FloridaDepartment of Colorectal Surgery2950 Cleveland Clinic BoulevardWeston FL 33331USAwexners@ccf.org

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Congress OfficeDuring the V Falk Gastro-Conference

The Westin Grand Hotel Telephone: +49 (0) 175 / 77 95 327Arabellastr. 6 Telefax: +49 (0) 89 / 92 64 92 0181925 MunichGermany

Opening Hours:Tuesday, February 7, 2012 16.00 – 21.00 hWednesday, February 8, 2012 7.30 – 18.00 hThursday, February 9, 2012 8.00 – 18.10 hFriday, February 10, 2012 8.00 – 18.15 hSaturday, February 11, 2012 8.00 – 18.10 h

Congress FeesScientific program of the Falk Symposium 182 € 200,-Students and residents € 100,-

* * * OR * * *

Day ticket € 120,-Students and residents € 60,-

The congress fees include:- Welcome Evening on February 7, 2012- Refreshments during coffee breaks- Lunch on February 10 and 11, 2012- A copy of the abstract volume

Admission to Scientific EventsFor admission to scientific events your name badge should be clearly visible.

Congress ReportThe official congress report of the Falk Symposium 182 “Carcinogenesis, Prevention and Treatment of Colorectal Cancer – State-of-the-Art 2012” will be published in English in the second half of 2012 by Karger Publishers, Basel, Switzerland. Orders for this book at a reduced subscription price of € 35,- can be placed at the Congress Office during the congress in Munich.

Congress Short ReportThe congress short report of the V Falk Gastro-Conference will be published by the Falk Foundation e.V. with number FSK 181-182 in the second half on 2012.Orders for this short report, free of charge, can be placed with the Falk Foundation e.V.

General Information:

FALK FOUNDATION e.V.Leinenweberstr. 579108 FreiburgGermany

Congress DivisionTelephone: +49(0)761/1514-0Telefax: +49(0)761/1514-359E-mail: symposia@falkfoundation.dewww.falkfoundation.org P

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