Post on 10-Jul-2015
Big Data in Healthcare
Prof Roberto Marcondes Cesar Junior Dr Alejandra Gonzalez-‐Beltran
R Baraniuk, Science, 2011
DNA sequencing technology
enabling clinical applicaCons with the goal of improving medical diagnosis and treatment
(personalised medicine)
hIp://www.genome.gov/sequencingcosts/
Mardis, A decade’s perspecCve on DNA sequencing technology Nature 2011
hIps://projects.ac/blog/five-‐top-‐reasons-‐to-‐protect-‐your-‐data-‐and-‐pracCse-‐safe-‐science/
ScienCfic data and the effect of poor research data management
hIp://www.nih.gov/news/health/oct2014/od-‐09.htm
hIp://goo.gl/BJuzWE
hIp://metadatacenter.org
hIp://goo.gl/BJuzWE
Data volume is only part of the story… in the conCnuum of translaConal research
From bench to bedside…
Data volume is only part of the story… in the conCnuum of translaConal research
A myriad of data types
Genes, genomes & variaCon
Literature
Clinical Gene, protein and metabolite
expression
Protein sequences, families & moCfs
Terminologies
Molecular Structures Chemical biology
Systems ReacCons, interacCons, pathways
in narraCve form semi-‐structure reports electronic health records
Imaging
Survey data
Data volume is only part of the story… in the conCnuum of translaConal research
A myriad of data types
Genes, genomes & variaCon
Literature
Clinical Gene, protein and metabolite
expression
Protein sequences, families & moCfs
Terminologies
Molecular Structures Chemical biology
Systems ReacCons, interacCons, pathways
in narraCve form semi-‐structure reports electronic health records
Imaging
Survey data
escience.ime.usp.br
Developments in genomics and molecular diagnosCcs in UK
100000 Genomes Project
Knowledge management infrastructure for translaConal research
Privacy, ConfidenCality & Ethical issues
Acknowledgements