Blending in Functional MRI

Wim Corbijn van Willenswaard

Chair WG16 (MRI)

Agenda

Functional MRI

Objects involved

How to combine the objects

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Functional MRI

Combining:• Anatomical data • Functional data• Registration (optional) to align data

Combined by:• Blending operation

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Anatomical data

Standard gray scale data (can be color)

Used to locate the area of the Functional activity

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Functional data

Parametric data describing relation between an voxel and the Functional activity

Can be:• Statistical parameter• Functional activation• Cardiovascular reactivity• Functional connectivity• Other

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Registration

Registration would be needed for

• Data having different Frame of Reference• Compensate for movements during the Assessment• Compensate for Image distortion

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Result

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View combining:- Anatomical image- 4 parametric maps

Using:• Thresholds• Opacity

Result

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Result

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Objects involved

Anatomical data:• Enhanced MR Image object (or other modality)

Functional data:• Parametric Map object

Registration data:• (Deformable) Spatial registration object

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Parametric map

Functional information Color

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FunctionalFloating pointinformation

Integer map Color map

Real world value mapping

Color LUT

Not present

Remark: Color LUT is present for integer map, but not for floating point

Combining Objects

Blending Presentation State• Combines two gray scale objects• Adds color to the object used for overlay• Defines opacity

• Not able to use the Parametric map• Not able to combine more than two objects

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How to continue

New Blending object:- Combining more than 2 objects- 2D Datasets (anatomical and parametric):

- Equal #slices- Equal geometry- NO Registration

- Allow coloring + opacity for every layer- Handles Threshold of parametric map- Enable Threshold contour display

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Parametric Map

Extensions needed:- Threshold information- Double / Floating point map Scalar for

coloring (Identity Pixel Value Transformation?)

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Not Covering

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Questions

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Questions

• Different number of frames• MPR / Geometry difference• Registration might need “MPR”• Threshold and Value representation / CP?• Leave out Tract set for now.• Anatomical can be a set of Classic Images• Can registration be used for parametric map• How to translate Floats to Colors• How to convey the meaning of a parametric Map RW value

reference or enhance the Parametric map• Store image pixel, in combination with RW value IOD/macro• Can we enhance the Alpha LUT transfer function to cope with

Threshold.

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Result

Combined:• Anatomical grayscale image• Parametric map

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Combining Objects

Option 2: (Planar MPR) Volumetric Presentation State• Combines multiple Volumetric objects• Extensive color capabilities for objects• Defines opacity

• Defines lot more than needed

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