BIOTECHNOLOGY

&

BIOCHEMICAL ENGG.

COMPILED Notes

For Indian students

The current task of biochemical

engineering research and development

is to integrate and develop the new

tools for the industrial applications. The

borders between the traditional

activities in bioprocessing, often called

upstream, reaction and downstream

processing, respectively, are becoming

more and more diffuse due to these

developments.

PERIODS OF BIOPROCESSES

• Pre-1800: Early applications & speculation

• 1800-1900: Significant advances in basic

understanding of biosciences

• 1900-1953: Genetics

• 1953-1976: DNA research, science knowledge

explodes

• 1977 – present modern technology

Penicillin – Sorona –

High – Fructose corn syrup

•

TEXT BOOKS.

1. M.L. Shuler and F. Kargi," Bio-process Engineering", 2nd Ed.,

Prentice Hall of India, N. Delhi, 2005

2 J.E. Bailey and D.F. Ollis," Biochemical Engineering Fundamentals",

2nd Edn., McGraw Hill, Publishing Co. New York., 1985.

3. P. Stanbury, A. Whitaker and S. J. Hall "Principles of Fermentation

Technology" 2nd Edn., Aditya Books (P) Ltd, N. Delhi.1997.

4. Biochemical Reaction Engineering, R. Lovitt and M. Jones, Chapter 5

in Chemical Engineering Vol 3, (third Edition), Richardson and Peacock,

1994, Asian Books (pvt) Ltd, N. Delhi.

5. Bioprocess Engineering: Systems Equipment and Facilities, Edited

by B.K.Lederson, N.A.D’elia and K.L.Nelson (1994), John Wiley and

Sons, N.Y.

Additional useful Reference books: Biosciences:

1. Fundamentals of biochemistry by J. L. Jain, S. Jain

and N. Jain [6th Ed.] S. Chand & Co, N. Delhi

2. Textbook of Biochemistry [Fourth Ed.], by Staunton-

Todd – Mason –Bruggen, Oxford & IBH Publishing Co

(Pvt) Ltd. N. Delhi.

3. Molecular Biology (Second Ed.) by David Freifelder,

Narosa Publishing House, N. Delhi.

Fundamentals of Biochemical Engineering, Rajiv Dutta,

2008, Springer, Ane Books India

Additional useful Reference books:

Biochemical Engineering:

1. Chemical Reaction Engineering, O. Levenspiel, Third Ed.

Part V, Biochemical Reaction Systems, pages 609 – 654,

chapters 27 to 30. Enzyme fermentation, Microbial

Fermentation, Substrate limiting fermentation, Product

limiting microbial limitation.

2. Biochemical Engineering, by Gummadi, Sathyanarayana

N. and Doble, Mukesh, Published by P H I, N. Delhi.

3. Biochemical Engineering: Principles and Concepts by

Inamdar and Syed Tanveer Ahamed. Published by P H I,

2007 New Delhi.

Bioprocess Engineering Principles, by Pauline M. Doran, 1995,

Elsevier Science & Technology Books

The primary aim of this book is to present the principles of bioprocess

engineering in a way that is accessible to biological scientists. It does not

seek to make biologists into bioprocess engineers, but to expose them to

engineering concepts and ways of thinking.

The chapters are organized around broad engineering sub-disciplines

such as mass and energy balances, fluid dynamics, transport phenomena

and reaction theory, rather than around particular applications of

bioprocessing. That the same fundamental engineering principle can be

readily applied to a variety of bioprocess industries is illustrated in the

worked examples and problems.

Govt. Depts. Supporting research in biotechnology in India

Over the years India has developed strengths in

biotechnology in public sector institutions. The graduation

from Biotechnology Development Board to Department of

Biotechnology in late eighties was a decisive step to

address a wider canvas in biotechnology. In these years

DBT has emerged as a major force to direct biotechnology

developments in India. Further, the involvement of various

agencies dealing with this technology has further helped

in developing technology capability at various levels. The

size of the industry is estimated to have grown to $1.5 to

$2.5billion between 1999 and 2002.