Determines barrier requirements

Effective packaging cost reduction tool

Best solution for extending shelf life

Reduced development time and cost

Measures effects of independent parameters: temperature, relative humidity and light

Estimates critical factors that determine failure mode Determines threshold values Determines needed barrier property Designs the final blister cavity using SolidWorks 3D Software Simulates Cavity Thinning & Moisture Permeation through FEA Software

Selects the most optimum packaging film

With BilcareOptima™, over-protection is avoided. We do this by placing your product through rigorous evaluation examinations, including our Forced Degradation Study which:

Research Services

BilcareOptima™

Is my packaging material the right choice?Which environmental parameters affect my products stability?How can I define the shelf life of my product? What is the best packaging for my product?How can I avoid “Over-Protection” for my product?

BilcareOptima™ gives you answers to the following questions:

Packaging Solutions, backed by Science

BilcareOptima™

The first scientific packaging development study that identifies the sensitivity profile of the product and recommends optimal packaging in 6 weeks. The highly sophisticated techniques practiced by BilcareOptima™ stand in significant contrast to the current packaging selection methods, which, in most cases, lead to over-protection. Over-protection is generally a consequence of not fully realizing a product‘s true barrier requirement.

Services & Solutions

BilcareOptima™ is a registered trademark of Bilcare Ltd.

Degradation pattern of formulation is evaluated using a set of designed experiments

Three fresh batches are studied under various climatic conditions to evaluate

Hygroscopicity Physical degradation Chemical degradation Drug release properties Hardness & friability Photo sensitivity Gas liberation

The blister is designed and thinning profile is modeled to predict real-life WVTR

BilcareOptima™

Bilcare Research Innovative Blister Films

ensuring optimal packaging

+

Water vapour transmission rate ASTM-1249, tropical conditions 38 °C, 90% r.h. , PVC film 250 mic, g/m² ·d.

Aclar ® 4000

Venus™

0,06

0

0,08Aclar ® 3000 0,08

0,11

Aclar ® 2000 0,11

Aclar ® 900 0,24

Aclar ® 20E 0,27

PVC/PVDC 120 g/m2 0,25

PVC/PVDC 90 g/m2 0,30PVC/PE/PVDC 90 g/m2 0,30

Aclar ® 160 0,35

PVC/PVDC 80 g/m2 0,35

PVC/PE/PVDC 60 g/m2 0,45

PVC/PVDC 40 g/m2 0,65

PVC/PE/PVDC 40 g/m2 0,65

PVC 3,30

130

0,06200

160

PVC/PVDC 60 g/m2 0,45

Research Services

BilcareOptima™

The BilcareOptima™ Methodology

AquaBa® is a registered trademark of Bilcare Research GmbHAclar® is a registered trademark of Honeywell (www.aclar.com)

Pharma PackagingInnovations

01/2012 EN

Bilcare Solutions Pharma Packaging Innovations info.optima.eu@bilcare.com bilcareoptima.com

Packaging Solutions, backed by Science

BilcareOptima™