Post on 03-Jan-2016
description
A effervescent tablet disinfectantA effervescent tablet disinfectantA effervescent tablet disinfectantA effervescent tablet disinfectant
Good
Effervescent !
Long Lasting !
High
Effectiveness !
Very Convenient !
Varied
Application !
SUNGIL PHARMASUNGIL PHARMAA concern ofA concern of
Features of Aquagard-TFeatures of Aquagard-T
• Good Effervescent !
• Long Lasting !
• High Effectiveness !
• Very Convenient !
• Varied Application !
Aquagard-T…Aquagard-T…
• Aquagard-T is a effervescent tablet
disinfectant.
• Aquagard-T is a very powerful disinfectant
containing sodium dichloroisocyanurate
(NaDCC) widely applied for the sterilization of
drinking water, or fighting against infectious
diseases, or act as disinfectant in raising
livestock, poultry and fish.
Aquagard-T…Aquagard-T…
• Aquagard-T is an oxidising compound which releases chlorine to produce hypochlorous acid and hypochlorite ion in the presence of water.
It is generally considered that the lethal action on organism is due to chlorination of cell protein or enzyme systems by nonionised hypochlorous acid, causing hydrolysis of peptidic chains of cellular membranes of pathogenic germs. Chlorine-releasing substances are bactericidal to most gram-positive and gram-negative bacteria, bacterial spores and viruses.
NaDCCNaDCC(Sodium Dichloroisocyanurate)(Sodium Dichloroisocyanurate)
(Structural formula of NaDCC)
NaDCCNaDCC(Sodium Dichloroisocyanurate)(Sodium Dichloroisocyanurate)
(Hydrolysis of NaDCC)
+ 2H2O
germicidal activity
+ 2HOCl
Hypochlorous acid
H+ + OCl-
Hypochlorite ion
• The germicidal activity of hypochlorous acid is 80 times higher than hypochlorite ion.
• The presence of HOCl in solution of chlorine containing compound
Aquagard-T : NaDCCAquagard-T : NaDCC(Sodium Dichloroisocyanurate)(Sodium Dichloroisocyanurate)
0
20
40
60
80
100
4 5 6 7 8 9 10
pH
HOCl, %
pH of Aquagard-
T solutions
pH of NaOCl
solutions
Chlorine containing Chlorine containing compoundcompound
Chlorine used widely as a disinfectant and bleaching agent
Inorganic compound Sodium hypochlorite (NaOCl)
Calcium hypochlorite (CaOCl)
Chloline dioxide (ClO2)
unstable, less germicidal activity
Organic compound Sodium dichloroisocyanurate (NaDCC)
very stable, predominantly germicidal activity
Features of Aquagard-TFeatures of Aquagard-T
Good effervescent high technique for making effervescent tablets
Long lasting free available chlorine is present for 5 days in Aquagard-T solutions
High effectiveness broad spectrum disinfectant (active to spore forming bacteria, naked
virus) Very convenient easy to handle and safe Varied application used widely for disinfection of poultry,
pig, cattle and sheep, livestock houses and facilities, drinking water
Very Sensitive
Septic bacteria
(Pasteurella sp)
Sensitive
Enveloped virus
(HC, TGE,
ILT, IB, ND)
Resistant
Non-enveloped virus
(Enterovirus,
Adenovirus, FMD,
IBD, Reo)
Very Resistant
Spore forming bacteria
(B. anthracis,
Clostridium)
Weak Disinfectantssurfactant,
quaternary ammonium chloride
Intermediate Disinfectants
cresol, phenol,
ortho, alcohol
Strong Disinfectants
chlorine, iodine,
Aldehydes,
ethylene oxide
Microbiocidal activity of Microbiocidal activity of various disinfectantsvarious disinfectants
Microbials NaDCC* (ppm)
Staphylococcus aureus 1.12
Escherichia coli 0.83
Salmonella typhi 0.83
Klebsiella pneumoniae 2.36
Serratia marcescens 1.14
Yersinia enterocolitica 0.72
Pseudomonas aeruginosa 2.00
Saccharomyces cerevisiae 72.0
Candida albicans 45.9
Microbiocidal activity of Microbiocidal activity of Aquagard-TAquagard-T
* Total available chlorine
Test strainsPhenol
coefficiency
Staphylococcus aureus 209P 28.5
Salmonella pullorum 9-25 25.5
Erysipelothrix rhusiopathiae 16.3
Erysipelothrix rhusiopathiae fujisawa
16.3
Bactericidal activity of Bactericidal activity of Aquagard-TAquagard-T
Phenol coefficiency of Aquagard-T against bacteria
Disinfectants
SporeBacillus subtilis
ATCC9372
Bacillus (natto) BN
strain
B. Cereus RIMD
0206001
Cl. Perfringens Type B
NCTC3182Aspergillus
oryzae
Aquagard-T 1:152(5) 1:57(15) 1:380(5)1:950(15) 1:3,800(15) 1:3,420(15)
Iodine 1:10(30) <1:10(30) 1:10(15) <1:10 1:1,000(15)
Benzalkonium chloride 1:150(5) 1:100(5) 1:50(5)
1:100(5) <1:10 1:1,500(15)
Amphotericsurfactant 1:50(15) 1:20(5)
1:25(15)1:10(5)
<1:50(15) <1:10 1:1,000(15)
Chlorhexidine
1:200(5)1:300(15) 1:100(15) 1:10(5)
<1:50(15) <1:10 1:1,200(15)
Bactericidal activity of Bactericidal activity of Aquagard-TAquagard-T
Effectiveness of Aquagard-T against spore forming
bacteria
Effective dilution rate, ( ) : Exposure time
Test strains NaDCC NaOCl Remarks
Bacillus cereus
17.2 1,060>62
times
Bacillus subtilis
30.9 1,510>49
times
Bactericidal activity of Bactericidal activity of Aquagard-TAquagard-T
The sporicidal activity of disinfectants
Adenovirus
IBD virusILT
virusND
virus
NaDCC ○ ○ ○ ○
Iodine × ○ ○ ○
Benzalkonium chloride
× × ○ ○
Virucidal activity of Aquagard-TVirucidal activity of Aquagard-T
Virucidal activity against poultry viruses
○ : inactivated, × : not inactivated
FMDvirus
Adeno
virus
JE viru
s
TGEvirus
Aujeszky’s disease
virus
Rota virus
HC virus
NaDCC ○ ○ ○ ○ ○ ○ ○
Iodine ○ × × × ○ × ○
Virucidal activity of Aquagard-TVirucidal activity of Aquagard-T
Virucidal activity against pig viruses
○ : inactivated, × : not inactivated
Test fungi MIC (mcg/ml) of Aquagard-T
Candida albicans 2.6
Candida krusei 26.3
Aspergillus niger 263.2
Aspergillus fumigatus 263.2
Penicillium citrinum 263.2
Trichophyton verrucosum 263.2
Microsporum canis 263.2
Trichophyton mentagrophytes 263.2
Fungicidal activity of Fungicidal activity of Aquagard-TAquagard-T
DisinfectantsChlorine
contents or dilution rate
Elapsed days (day)
0 1 3 5
Aquagard-T 418ppm - - - 2.0×103
NaOCl 418ppm - - 2.4×105 1.7×105
Quaternary ammonium chloride 1:200 - - 7.0×102 8.3×105
Iodine 1:250 - - 4.0×101 7.0×103
Orthodichlorobenzene 1:250 - 2.0×103 7.0×103 8.7×103
Control - - 5.0×104 2.0×108 3.2×107
The efficacy test scopeThe efficacy test scope
Total bacterial colony counts on foot bath in entrance of farm
Unit : CFU/ml, - : <1×101CFU/ml
Bactericidal activityBactericidal activity
• Method : According to regulation of NVRQS • Experiment : Research Institute for Veterinary Science in Konkuk
Univ.• Results :
DiseaseCondition
Light waterOrganic
substance
Salmonella spp. 1:7,200 1:540
Brucella spp. 1:3,500 1:400
Streptococcus spp. 1:8,000 1:720
Virucidal activityVirucidal activity• Method : According to regulation of NVRQS • Experiment : Research Institute for Veterinary Science in
Gyeongsang National Univ. and Cheonbuk National Univ.• Results :
DiseaseCondition
Light waterOrganic
substance
Hog cholera virus 1:12,000 1:1,000
PRRS virus 1:12,500 1:750
New castle virus 1:9,000 1:1,000
Avian Influenza Virus 1:15,000 1:500
Avian Pneumovirus 1:700 1:50
Inclusion Hepatitis virus 1:500 1:100
• Each tablet (13g) contains
5g of Sodium dichloroisocyanurate(= 3g of available chlorine)
and
Component A(effervescent agent)
Component B (pH controlling agent)
Composition of Aquagard-TComposition of Aquagard-T
• Disinfection of virus and bacteria in livestock housing, farms (floor, wall), facilities and equipment, the animal body
• Drinking water treatment
• Teat dip or spray (mastitis prevention)
• Disinfection of pathogen – General bacteria (Salmonella spp.), Brucella spp.,
Streptococcus spp. and so on.
– Foot and Mouth Disease virus, Hog Cholera virus, PRRS virus, Newcastle Disease virus, Avian Influenza Virus, Avian Pneumovirus, Inclusion Body Hepatitis virus and so on
Application of Aquagard-TApplication of Aquagard-T
Use of Aquagard-TUse of Aquagard-T(Bacteria)(Bacteria)Recommended Dilution Rate
Disinfection Target
LowContamination Group
HighContamination Group
Livestock building, the surface of the animal's
body, equipment, General automobiles
The Floor of the Livestock building, Manure,
the body of the animal (dead or alive),
Automobiles/Vehicles
General Bacteria(Salmonella spp.)
1:7,200(1tablet per 93L of water)
1:540(1tablet per 7L of water)
Brucella spp.1:3,500
(1tablet per 45L of water)1:400
(1tablet per 5L of water)
Streptococcusspp.
1:8,000(1tablet per 104L of water)
1:720(1tablet per 9.3L of water)
* Dilution rate is the most effective dilution rate of results of determination of the efficacy of disinfectant against general bacteria and specific pathogen.
Use of Aquagard-TUse of Aquagard-T(Virus)(Virus)
Recommended Dilution Rate
Disinfection Target
Low Contamination Group High Contamination Group
Livestock building, the surface of the animal's body, equipment,
General automobiles
The Floor of the Livestock building, Manure, the body of
the animal (dead or alive), Automobiles/Vehicles
Hog Cholera virus1:12,000
(1 tablet per 156L of water)1:1,000
(1 tablet per 13L of water)
PRRS virus1:12,500
(1 tablet per 163L of water)1:750
(1 tablet per 9.7L of water)
ND virus1:9,000
(1 tablet per 117L of water)1:1,000
(1 tablet per 13L of water)
Avian Influenza Virus
1:15,000(1 tablet per 195L of water)
1:500(1 tablet per 6.5L of water)
Avian Pneumovirus
1:700(1 tablet per 9L of water)
1:50(1 tablet per 650ml of water)
Inclusion body hepatitis virus
1:500(1 tablet per 6.5L of water)
1:100(1 tablet per 1.3L of water)
* Dilution rate is the most effective dilution rate of results of determination of the efficacy of disinfectant against general bacteria and specific pathogen.
Use of Aquagard-TUse of Aquagard-T(Water Treatment)(Water Treatment)
• Dissolve Aquagard-T in water tank every other day or
every day if necessary.
• Dilute 1 tablet per 500 ~ 750 L of drinking water
according to water quality and farm condition.
Use program for poultryUse program for poultry
• Poultry houses and facilities - Thorough cleaning with water - Spray Aquagard-T solution not less than 2 times
before placement of chicks. - Spray Aquagard-T solution during growing period if necessary.
Use program for poultryUse program for poultry
• Foot bath - For disinfect boots by dipping before entering
each house, replace the Aquagard-T solutions every 5 days or sooner when soiled by heavy use.
• Transport - For prevention of disease transmission through
trucks and crates by disinfecting them with Aquagard-T.
- Use in wheel baths and renew every 5 days or according to volume of traffic.
Use program for dairyUse program for dairy
• Dairy houses and facilities - Thorough cleaning with water - Spray Aquagard-T solution, eliminate all
bacteria, viruses and fungi.
Use program for dairy to prevent Use program for dairy to prevent MastitisMastitis
• Preparation of disinfection– Dissolve 1 Aquagard-T tablet per 1L
of water and move to dipping cup or sprayer for disinfection.
• Prior to milking - Clean milk starts with clean teats. - Teat and udder spraying will remove
all bacteria, viruses and fungi.
• After milking - Teat dip or spraying will decontaminate the teats and
prevent mastitis
Use program for MilkingUse program for Milking
1) Disinfection prior to milking- Removal of contaminant on teat
Dipping method Spray method
2) Removal of disinfectant- With clean and disinfected towel
3) Prior to milking- More than 5 times
4) Massage and final cleaning
- With clean and disinfected towel
5) Attaching the milking mashing- Vacuum-blocking
6) Disinfection after milking- Prevention of teat canal
Package of Aquagard-TPackage of Aquagard-T
• 10 tablets / plastic container• 100 tablets (1.3kg) / plastic container• 2,000 tablets / carton
Storage and shelf-life of Storage and shelf-life of Aquagard-TAquagard-T
• Storage Keep under cool and dry conditions
and protect from light
• Shelf-life 24 months after manufacturing
Efficacy Test ReportEfficacy Test Report
Effect of Aquagard-T on E. Coli in WaterEffect of Aquagard-T on E. Coli in Water
Precautions of Aquagard-TPrecautions of Aquagard-T
• Keep out of reach of children.• Do not dissolve in strong alkali (over pH 10) or
acidic (below pH 3) solution.• Do not exceed the recommended dosage.• For 5 days, from before 2 days to after 2 days
of vaccination, do not disinfect drinking water.• Do not place near fire or strong inflammables.• Do not place in metallic vessel more than 2
hours.• In case of drink diluted solution, immediately
seek for medical advice.
SUNGIL PHARMASUNGIL PHARMAA concern ofA concern of