Apoptosis

Types

Cell Injury

?

Cell

Death

NECROSIS

APOPTOSIS

Apoptosis

Coordinated Programmed

cell death

Coordinated Programmed

Cell Death

Apoptosis

* Falling off

* Dropping off

Features of Apoptosis

Involvement of single/group of cells.

Shrinkage of cell

Formation of Apoptotic bodies

No Acute Inflammatory reaction

Phagocytosis

Molecular Mechanism

Simplyfy

Mechanism of Apoptosis

Cascade of molecular events

culminating In to activation of

caspases.

Initiation

Death Signals

Death receptors : Type 1 TNF receptor

EXTRINSIC (DEATH

RECEPTOR) PATHWAY

Bcl 2 , Bcl x

Anti-Apoptotic Proteins

Bak, Bax, Bim

Pro Apoptotic Proteins

Cytochrome C Apaf-1

Caspase 9

INTRINSIC (Mitochondrial)

PATHWAY

Execution Phase

Caspase 8 and 9 :

Initiator Caspase

Caspase 3 and 6 :

Executioner Caspase

Apoptotic Bodies and

Phagocytosis at the end…

p53 gene

Programmed Cell Deatha step ,

towards “Life”

Cell Death : Necrosis / Apoptosis

Features of ApoptosisInitiation (2 Pathways) & Execution

p53Anti Apoptotic genesBcl 2 , Bcl x

Pro Apoptotic genes

Bak Bax Bim

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