A SYSTEM AND DEVICE FOR FOCAL tDCS: HIGH–DEFINITION(HD) tDCS

Abhishek DattaJeff Borckardt, Mark George, Mar Cortes, Dylan Edwards, Felipe Fregni, Eric

Wassermann, Marom Bikson

Neural Engineering Laboratory - Department of Biomedical Engineering

The City College of New York of CUNYNeuromodulation Laboratory, Spaulding Rehabilatation Hospital Harvard Medical School

-application of currents delivered through the scalp to modulate brain activity.

TRANSCRANIAL DIRECT CURRENT STIMULATION (tDCS)

-number of disorders, rehabilatation and cognitive enhancement

-safe,easy to apply, CHEAP!

SPATIAL TARGETING

Brain

Stimulation Electrodes

Current flow and brain

modulation

“Conventional” Sponge-based Transcranial DC Stimulation

SPATIAL TARGETING

Brain

Stimulation Electrodes

Current flow and brain

modulation

“High-Definition (HD)” Transcranial DC Stimulation

“Ring” Configuration

High-definition (HD)

Transcanial

(4x1 Ring)

Conventional

Transcanial

(large pad)

FEM ANALYSIS OF TRANSCRANIAL ELECTROTHERAPY FOCALITY

“CONVENTIONAL” tDCS

Min Max

Electric field

1 mA Datta et al., 2009

“CONVENTIONAL” tDCS

HIGH DEFINITION (HD)- tDCS

Min Max

Electric field

2 mA

HIGH DEFINITION (HD)- tDCS

Datta et al., 2009

HD tDCS – 4x1

Hardware Development Clinical Trials

NIH-NINDSEric Wassermann, Egas Caparelli Dáquer

MUSCMark GeorgeJeff Borckardt

Burke RehabilitationDylan EdwardsMar Cortes

Harvard (Spaulding)Felipe Fregni

…….

Soterix Medical

PILOT CLINICAL STUDY 1: EXPERIMENTAL PAIN (MUSC)

“Setup”

PILOT CLINICAL STUDY 1: EXPERIMENTAL PAIN (MUSC)

Borckardt et al., under review

Analgesic effects in an experimental pain model……

Significant effect for sensory thresholds.

Edwards et al., under review

Targeting Validation

PILOT CLINICAL STUDY 2: COMBINED TES & MODELING (BURKE REHABILATATION)

Transcranial Electrical Stimulation (TES) – short high-intensity pulse that triggers motor response (MEP)

ANODE:C3 CATHODE:FC5,FC1,CP5,CP1

PILOT CLINICAL STUDY 2: COMBINED TES & MODELING (BURKE REHABILATATION)

ANODE:F3CATHODE:AF7,AFz,FC5,FC1

ANODE:P3CATHODE:CP5,CP1,PO7,POz

Peak

0

Ele

ctric

fie

ld/C

urr

en

t d

en

sity

33%

66%

Edwards et al., under review

-Retains advantages of conventional therapy

ADVANTAGE OF HD CONFIGURATIONS:

Other configurations can be used: (4 X 4, 5X2…) based on application

-Cortical regions can be “selectively targeted” using a HD system.

-Customizable (individualized therapy)

Procedures, implants…

Skull Defects / TBI

Stroke