Post on 03-Apr-2018
7/28/2019 9A23601 Computational Molecular Biology
http://slidepdf.com/reader/full/9a23601-computational-molecular-biology 1/4
Code: 9A23601
B.Tech III Year II Semester (R09) Regular & Supplementary Examinations, April/May 2013
COMPUTATIONAL MOLECULAR BIOLOGY(Biotechnology)
Time: 3 hours Max Marks: 70Answer any FIVE questions
All questions carry equal marks
*****
*****
1 (a) What is dynamic programming? Discuss in detail its principles with an example.
(b) Describe any two biological problems that can be solved by using dynamic programming.
2 (a) Discuss in detail the significance of DNA sequence.
(b) Explain homology based gene prediction.
3 What are microarrays? Discuss in detail the process of microarray technology with an
example.
4 Discuss the different methods available for structure determination of proteins.
5 (a) Write about protein homology modeling.
(b) Discuss the protein design emphasis on structural bioinformatics.
6 (a) Discuss the rooted phylogenetic tree.
(b) Discuss the weighted parsimony method for construction of phylogenetic trees.
7 What are dendrograms? Discuss the distance based methods for construction of phylogenetic
trees.
8 Discuss in detail how computational tools aid in drug discovery.
1
7/28/2019 9A23601 Computational Molecular Biology
http://slidepdf.com/reader/full/9a23601-computational-molecular-biology 2/4
Code: 9A23601
B.Tech III Year II Semester (R09) Regular & Supplementary Examinations, April/May 2013
COMPUTATIONAL MOLECULAR BIOLOGY(Biotechnology)
Time: 3 hours Max Marks: 70Answer any FIVE questions
All questions carry equal marks
*****
*****
1 Define transcription. How transcription is used for global expression analysis?
2 (a) Discuss in detail how computational molecular biology differs with basic molecular biology.
(b) Differentiate functional genomics and comparative genomics.
3 Discuss in detail the structural properties of proteins leading to stability.
4 What is microarray? Explain its procedure in detail with example.
5 What is single nucleotide polymorphism? How is it helpful in analyzing genetic disorders?
6 (a) structure predication of protein.
(b) Protein threading.
7 Discuss in detail the rational drug design.
8 (a) What is dendrograms? Write about its significance.
(b) Write about dendrograms and its interpretation.
2
7/28/2019 9A23601 Computational Molecular Biology
http://slidepdf.com/reader/full/9a23601-computational-molecular-biology 3/4
Code: 9A23601
B.Tech III Year II Semester (R09) Regular & Supplementary Examinations, April/May 2013
COMPUTATIONAL MOLECULAR BIOLOGY(Biotechnology)
Time: 3 hours Max Marks: 70Answer any FIVE questions
All questions carry equal marks
*****
*****
1 Discuss the various involved in the graphical representation of biochemical systems.
2 (a) Applications of SNP.
(b) EST approach.
3 Discuss in detail the steps involved in microarray analysis.
4 Discuss in detail the various tools to predict the secondary structure of proteins.
5 (a) Write about protein homology modeling.
(b) Discuss the protein design emphasis on structural bioinformatics.
6 What are dendrograms? Discuss in detail the different types od dendrograms.
7 Discuss in detail the basic concepts in evolution to its molecular level.
8 Discuss in detail the different phases of drug discovery cycle to its formulation.
3
7/28/2019 9A23601 Computational Molecular Biology
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Code: 9A23601
B.Tech III Year II Semester (R09) Regular & Supplementary Examinations, April/May 2013
COMPUTATIONAL MOLECULAR BIOLOGY(Biotechnology)
Time: 3 hours Max Marks: 70Answer any FIVE questions
All questions carry equal marks
*****
*****
1 Add notes on:
(a) S-system equations.
(b) Steady state analysis with an example.
2 (a) Discuss in detail the significance of DNA sequence.
(b) Explain homology based gene prediction.
3 Discuss in detail the steps involved in microarray analysis.
4 (a) Write about protein homology modeling.
(b) Discuss the protein design emphasis on structural bioinformatics.
5 Discuss in detail the structural properties of proteins leading to stability.
6 (a) Discuss the rooted phylogenetic tree.
(b) Discuss the weighted parsimony method for construction of phylogenetic trees.
7 (a) What is dendrograms? Write about its significance.
(b) Write about dendrograms and its interpretation.
8 Discuss in detail the rational drug design.
4