Leukemia

Ramon QiuAlex Dao2009StanfordE25

Asian American Donor Program

Modest beginnings in 1989

123 Asian donors in national registry

Encourage typing of minorities

Launched Latino Outreach Program in 2008

ΛΦΕ

Lambda Phi Epsilon is the first and only international Asian American interest fraternity

Our National Philanthropy: Raise awareness for Leukemia

AADP

What is Leukemia?

From Lecture:

Leukemia is a cancer of a white blood cell. For example, B cell leukemia is when B cells proliferate indefinitely.

Four Types of Leukemia:

Acute Myelogenous Leukemia (AML)

Acute Lymphocytic Leukemia (ALL)

Chronic Myelogemous Leukemia (CML)

Chronic Lymphocytic Leukemia (CLL)

Four Types of Leukemia:

Acute Myelogenous Leukemia (AML) – Most common form

Acute Lymphocytic Leukemia (ALL)

Chronic Myelogemous Leukemia (CML)

Chronic Lymphocytic Leukemia (CLL)

Four Types of Leukemia:

Acute Myelogenous Leukemia (AML) – Most common form

Acute Lymphocytic Leukemia (ALL) – Most common in children

Chronic Myelogemous Leukemia (CML)

Chronic Lymphocytic Leukemia (CLL)

Four Types of Leukemia:

Acute Myelogenous Leukemia (AML) – Most common form

Acute Lymphocytic Leukemia (ALL) – Most common in children

Chronic Myelogemous Leukemia (CML) – More common in adults

Chronic Lymphocytic Leukemia (CLL)

Four Types of Leukemia:

Acute Myelogenous Leukemia (AML) – Most common form

Acute Lymphocytic Leukemia (ALL) – Most common in children

Chronic Myelogemous Leukemia (CML) – More common in adults

Chronic Lymphocytic Leukemia (CLL) – Only occurs in adults

Acute Myelogenous Leukemia (AML)

Most common form (occurs in adults and children)

Most dangerous (fastest acting)

Begins with 1 cell

Begins with 1 cell

Cell multiplies into trillions of copies

Begins with 1 cell

Cell multiplies into trillions of copies

Red blood cells under produced (anemia)

Begins with 1 cell

Cell multiplies into trillions of copies

Red blood cells under produced (anemia)

White blood cells under produced (immune system failure)

Begins with 1 cell

Cell multiplies into trillions of copies

Red blood cells under produced (anemia)

White blood cells under produced (immune system failure)

Platelets under produced (stops blood clotting)

http://images.the-scientist.com/content/images/articles/23273/ecology_infoL.jpg

Event 1: BCR-ABL, MLL-ENL, AML1-ETO, etc… Expression of these genes inhibits cell differentiation

Forces cells to copy the Leukemia cell.

Event 1: BCR-ABL, MLL-ENL, AML1-ETO, etc…

Event 2: Anti-senescenceSenescence is a mechanism that forces cells to stop dividing

Leukemia cells disable this mechanism

Event 1: BCR-ABL, MLL-ENL, AML1-ETO, etc…

Event 2: Anti-senescence

Event 3: Anti-apoptoticApoptosis is a mechanism where a cell destroys itself

Apoptosis is necessary when a cell is damaged or infected

Leukemia cells disable this mechanism

Event 1: BCR-ABL, MLL-ENL, AML1-ETO, etc…

Event 2: Anti-senescence

Event 3: Anti-apoptotic

Event 4: Apoptosis receptor pathway silencedApoptosis can also be triggered from surrounding tissue

Same idea as Event 3

Event 1: BCR-ABL, MLL-ENL, AML1-ETO, etc…

Event 2: Anti-senescence

Event 3: Anti-apoptotic

Event 4: Apoptosis receptor pathway silenced

Event 5: Evade immune cellsEvents 1-4

Event 1: BCR-ABL, MLL-ENL, AML1-ETO, etc…

Event 2: Anti-senescence

Event 3: Anti-apoptotic

Event 4: Apoptosis receptor pathway silenced

Event 5: Evade immune cells

Event 6: Activate and over express self renewal path genes

http://images.the-scientist.com/content/images/articles/23273/ecology_infoL.jpg

Treating Leukemia

Induction Therapy

Consolidation Therapy

Induction Therapy

Induction TherapyChemotherapy

Induction TherapyChemotherapy

Kill as many AML cells as possible

Induction TherapyChemotherapy

Kill as many AML cells as possible

Achieve remission

Induction TherapyChemotherapy

Kill as many AML cells as possible

Achieve remission

3-4 weeks

Induction TherapyChemotherapy

Kill as many AML cells as possible

Achieve remission

3-4 weeks

Consolidation Therapy

Induction TherapyChemotherapy

Kill as many AML cells as possible

Achieve remission

3-4 weeks

Consolidation TherapyMore chemotherapy

Induction TherapyChemotherapy

Kill as many AML cells as possible

Achieve remission

3-4 weeks

Consolidation TherapyMore chemotherapy

Stem cell transplant

Induction TherapyChemotherapy

Kill as many AML cells as possible

Achieve remission

3-4 weeks

Consolidation TherapyMore chemotherapy

Stem cell transplant

Get blood cell count back to normal

Induction TherapyChemotherapy

Kill as many AML cells as possible

Achieve remission

3-4 weeks

Consolidation TherapyMore chemotherapy

Stem cell transplant

Get blood cell count back to normal

Take immunosuppressant drugs

Myths and Facts

Myth: Donating Bone Marrow is Painful

Myth: Donating Bone Marrow is Painful

Fact: Anesthesia is always usedDonors feel no pain or needle injectionsDonors feel a little pain in the lower back a few

days after the procedure

Myth: Donating Bone Marrow involves surgery

Myth: Donating Bone Marrow involves surgery

Fact: Majority of donations do not involve surgeryUsually taking peripheral blood stem cells is

enough

Myth: Pieces of Bone are removed from the donor

Myth: Pieces of Bone are removed from the donor

Fact: Majority of donations involve taking only bloodIn marrow donation, only marrow is taken from

inside bone, not the bone itself

Myth: Donating Bone Marrow is dangerous

Myth: Donating Bone Marrow is dangerous

Fact: The procedure is relatively safe and there are rarely any long term side effects from donating

All the donated marrow is replenished within 1 month

Myth: Bone Marrow donation involves a lengthy recovery

Myth: Bone Marrow donation involves a lengthy recovery

Fact: Most donors take the drug filgrastim and experience minor symptoms that disappear 2 days after donating

Marrow donors will feel tired and some soreness for less than a week, with all symptoms disappearing

after 2-3 weeks

Nick Glasgow

Nick Glasgow

• 28 years old• Diagnosed with AML

in March 2009• 75% Caucasian and

25% Japanese• Desperately needs

your HELP

What you can do NOW• Where do I register?

You can register in one of three ways:

1.) Visit a local drive near you.

2.) Call or e-mail AADP for a HOME-TEST KIT if you cannot attend a drive.

•3.) Visit the AADP office in Alameda or a local donor center in Stanford, Oakland, or Sacramento, to register in person. Appointments must be made beforehand.

• 4.) Encourage family/friends/dormmates/fraternity brothers/sorority sisters to get their bone marrow typed!

Thank you for registering.

SAVE A LIFE TODAY!