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DATA MINING:

INVESTIGATING IVF MODELS

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9% of married couples in the US are medically infertile (age 15-44) = 2.3 million couples.

An additional 19% of couples have impaired ability to have children.

Total = ~7.2 million couples

From 1998 National report from Center for Disease Control

Why IVF?

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IVF Procedure:

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Many diagnoses:

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Concerns:• Less than 1/3 of IVF cycles are successful.

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Concerns:• Less than 20% of cycles result in single pregnancy.

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Concerns:• Usually many embryos are transferred.

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Concerns:• Some result in multiple births.

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Concerns:• How to predict individual patient results.

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The Data:• 12 months of statistics from 678 cycles.• Over 100 attributes for each record.

Procedural

PatientTechnology

Patient Procedural Technology

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The Data:• Procedural includes info on drug protocols, #oocytes, #blasts, embryo transfer, trauma and other cycle specific data.

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The Data:• Patient info includes patient specific data such as diagnosis, BMI, and age.

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The Data:• Technology information includes incubators, doctors, ICSItech, and catheter type among others.

ICSI (intracytoplasmic sperm injection)

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Data Mining:• A cyclical procedure.

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Data Understanding & Cleaning:• # > or = 6 Cell• Diagnoses• Day of Embryo Transfer

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Sensitivity analysis using entropy reduction:

2log ( )ik ikk

p p Entropy formula:

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Model Assessment:

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DATA MINING:

INVESTIGATING IVF MODELS