1 B Actino

Actinomycetes

Actinomycetes (order)

Three genera

Actinomyces species Nocardia species Streptomyces species

Gram Positive Filamentous Bacteria

GENUS OXYGEN GRANULE ACIDFAST

Mycobacteria aerobe no yes

Actinomyces ANAEROBE YES no

Nocardia aerobe sometime

PARTIALLY

Streptomyces aerobe YES no

Actinomycosis

A chronic suppurative and granulomatous disease of the cervico-facial, thoracic or abdominal areas

Actinomycosis

Actinomyces israelii

Ecological Niche

Actinomyces

Endogenous (man and animals)

CLINICAL SPECIMENSActinomyces

Sulphur

granules

Drug of Choice

Penicillin

(large doses)

Serological Test

None available

Nocardiosis

Subcutaneous infections, pulmonary infections, and brain abscesses

Ecological Association

SoilEndogenous ?

Geographic Distribution

World wide

Nocardiosis

N. asteroides – Pulmonary

N. brasiliensis - Abscesses

Clinical Specimens

Sputum Pus Biopsy tissue

Serological Test

None available

Drug of Choice

Sulfamethoxazole-Trimethoprim

STREPTOMYCOSIS

Streptomyces species

Mycetoma

Streptomyces species

Ecological Association

Streptomyces may invade bone

Clinical specimens

Pus Biopsy material

Serological Test

None available

Treatment

Surgical debridement Sulfa drugs Amphotericin B

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